The altitudinal gradient in, and absolute values of, growing

At pH 5, ds DNA was found to complex with the pH responsive copolymers at a N/P molar ratio above 2:1, which assisted the encapsulation of ds DNA in the polymersomes, while low association was observed at pH 7.4. Cytotoxicity studies performed on folate receptor overexpressing KB and B16 “F10 cells and low folate receptor expressing MCF 7 cells showed high tolerance of the polymersomes at up to 3 mg/mL concentration. Studies performed with red blood cells showed that at pH 5.0 the polymersomes have endosomolytic properties.

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